Oncology Radiotracers

FDG is far and away the most widely used PET tracer being used for nearly all clinical PET scans. Many other tracers are under development and are likely to see widespread use, both in the clinic and for research, within the next ~5 years. These include:

Validating new radiotracers such as these and making them widely available is one of the main challenges that needs to be addressed in order to realise the full potential of PET imaging.

This research directory (updated June 2011) summarises the PET radiotracers with established or promising oncology applications which are currently being produced in the UK. The directory lists companies and academic sites that can potentially supply the radiotracer either on a commercial basis or as part of an academic collaboration. The directory states whether the tracer is manufactured to GMP grade.

Please note that the list is not exhaustive and there may be other sites and tracers that are not currently included. In addition, while a tracer may already be in use for some studies, this does not necessarily mean that it will not be considered an Investigational Medicinal Product (IMP) by the Medicines and Healthcare products Regulatory Agency (MHRA). If there is doubt about the IMP status then this should be confirmed with the MHRA.

A list of IMPDs is available on the EANM website.

GMP-Grade Radiopharmaceuticals Application Potential Commercial Suppliers Potential Academic Suppliers
[64Cu]-(diacetyl-bis(N4-methylthiosemicarbazone) (ATSM) Hypoxia KCL
[61Cu]-(diacetyl-bis(N4-methylthiosemicarbazone) (ATSM) Hypoxia KCL
[18F]-Fluoromisonidazole (FMISO) Hypoxia Cambridge, KCL
[18F]-Fluorodeoxyglucose (FDG) Glucose Metabolism Erigal, IBA, PETNET (all sites) Aberdeen, Cambridge, Edinburgh, KCL
[18F]-Sodium Fluoride (NaF) Bone Scanning Erigal, IBA, PETNET (Mt Vernon) Aberdeen, Edinburgh, KCL
[18F]-Fluorothymidine (FLT) Cellular Proliferation PETNET (Nottingham) Cambridge, KCL, Manchester
[18F]-Fluoroethylcholine Lipid Metabolism Erigal (Sutton), PETNET (Mount Vernon)
[18F]-Fluoromethylcholine Lipid Metabolism KCL
[18F]-3,4-dihydroxy-6-18F-fluoro-L-phenylalanine (F-DOPA) Neuroendocrine tumours Manchester
[11C]-Choline Lipid Metabolism Aberdeen, KCL
[11C]-Methionine Amino-acid Metabolism Aberdeen, Cambridge, KCL, Manchester
[11C]-Verapamil P-glyoprotein transporter Manchester
[11C]-methylglucose Glucose Transport Cambridge
[11C]-Antisense Apoptosis (very specific function) Manchester
[11C]-Metomidate 11b-hydroxylase marker Cambridge
[15O]-Water Blood flow Erigal (Sutton) Aberdeen, Cambridge, KCL, Manchester
[15O]-Carbon monoxide Blood volume Cambridge, Manchester
[15O]-Oxygen Oxygen metabolism Cambridge

Non-GMP Grade Radiopharmaceuticals Application Potential Commercial Suppliers Potential Academic Suppliers
[18F]-Sodium Fluoride (NaF) for 18F synthesis Erigal
[64Cu]-(diacetyl-bis(N4-methylthiosemicarbazone) (ATSM) Hypoxia Cambridge
[18F]-Fluoroazomycin arabinoside (FAZA) Hypoxia Cambridge
[11C]-Butanol Blood flow Cambridge

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